The Vault

• 9-Me-BCMotivation & dopamine Supports dopamine synthesis and the repair of dopamine neurons after too many stimulants. Animal data
• ACD-856Focus & memory Memory and brain resilience in animal studies. Early human safety trials completed. Limited human data
• AdamaxFocus & memory Users report Semax-like focus and drive that lasts longer. User reports only
• AF710BFocus & memory Protects the brain through two different systems at once. Animal data
• AlbuterolBody composition Raises energy use a little and helps hold muscle in a deficit. Limited human dataPrescription drug
• ATX-304Body composition Mimics part of the effect of cardio: more fat and sugar burned, and a higher resting metabolic rate. Limited human data
• BAM15Body composition Raises how much energy you burn at rest. In mice it caused fat loss without eating less. Animal data
• BPC-157Recovery & longevity Speeds healing of tendons, ligaments, muscle and the gut, in animal studies. Animal data
• BromantaneMotivation & dopamine Raises dopamine production on a different pathway from 9-Me-BC, so the two complement each other. Human data
• BuspironeCalm & mood Works on serotonin (5-HT1A) without sedation. Human dataPrescription drug
• CB-03-01Skin Cuts the hormone-driven oil that causes acne, without affecting hormones in the rest of the body. Human data
• CerebrolysinBrain protection Recovery and brain protection. Human trials in stroke and dementia show mixed but sometimes positive results. Human data
• ClonidineSleep Calms the wired, fight-or-flight feeling, especially on stimulants or androgens. Human dataPrescription drug
• ColuracetamFocus & memory Memory in animal models of impaired acetylcholine. People also report clearer vision and mood. It was trialled in humans for depression with anxiety. Limited human data
• DaridorexantSleep Switches off the 'stay awake' signal instead of knocking you out. Human dataPrescription drug
• DihexaFocus & memory Builds new synapses, for memory that sticks. Animal data
• DSIPSleep Sleep onset and depth. Older human studies are small and mixed. Limited human data
• Emoxypine (Mexidol)Calm & mood Antioxidant brain protection. "Might be literally the best neurological protection agent I've ever seen." Limited human data
• EpitalonRecovery & longevity Sleep rhythm and markers of cell ageing. Animal data
• FasoracetamFocus & memory Calm focus and mood. Some people use it to soften the comedown from stimulants. Limited human data
• GB-115Calm & mood Hits anxiety through CCK, a different pathway from GABA. Animal data
• GHK-CuHair Helps skin repair and fades marks left after breakouts. Limited human data
• IDRA-21Focus & memory Learning and memory in animals, with effects lasting well beyond the dose. Animal data
• Intranasal insulinFocus & memory Supports brain energy and memory, and has real human data behind it. Human dataPrescription drug
• IsotretinoinSkin Clears stubborn acne, often for good. Human dataPrescription drug
• J147Brain protection Supports brain energy and healthy ageing. A personal favourite. Animal data
• KW-6356Motivation & dopamine The wakefulness and motivation piece. Be careful, the half-life is long. Limited human data
• KY19382Hair Pushes resting follicles back into the growth phase. Animal data
• L-THPSleep Turns down the dopamine drive that keeps your mind racing at night. Limited human data
• MemantineMotivation & dopamine Used to slow tolerance to phenibut and other calming compounds, so they keep working. Limited human dataPrescription drug
• MinoxidilHair The proven base layer for keeping and regrowing hair. Human data
• MOTS-cRecovery & longevity Exercise capacity and blood-sugar control, in animal studies. Animal data
• NAD+Recovery & longevity Supports cell energy and repair. Human data
• NefiracetamFocus & memory For learning new material. Limited human data
• NoopeptFocus & memory Quick, short-lasting lift in focus and recall. Studied in Russia for mild cognitive problems after vascular disease or head injury. Limited human data
• NSI-189Calm & mood For mood when stimulants leave you flat. Limited human data
• OxytocinCalm & mood Closeness and connection. Human data
• PE-22-28Calm & mood Neuroplasticity, to help new learning stick. Animal data
• PhenibutCalm & mood Social ease and a relaxed, talkative feeling, much like a couple of drinks. Limited human data
• PhenylpiracetamFocus & memory Sustained attention, saved for when you really need it. Limited human data
• PicamilonCalm & mood Takes the edge off a racing mind before bed. Limited human data
• PinealonSleep Brain protection and sleep quality in animal and small Russian studies. Animal data
• PregabalinCalm & mood Calms overactive nerve signalling through α2δ. Human dataPrescription drug
• PRL-8-53Focus & memory Word and fact recall. One small human study (1978) found better recall, mostly in people who started with weaker memory. Limited human data
• PT-141Sexual health Raises desire and arousal, which tadalafil does not touch. Human data
• Pyrilutamide (KX-826)Hair Blocks DHT signalling at the scalp. Limited human data
• SANA (MVD1)Body composition Makes fat cells burn energy as heat. It caused weight loss in mice, and a first human study has been published. Limited human data
• SelankCalm & mood Calms the anxiety that keeps you up, without sedating you. Limited human data
• SeltorexantSleep Quiets the 'stay awake' signal so you fall asleep without heavy sedation. Human data
• SemaxFocus & memory Mental energy and focus without a stimulant crash. Raises BDNF in animal studies. Limited human data
• SLU-PP-915Body composition More endurance and more fat burned for fuel, in mice. Animal data
• TadalafilSexual health Stronger, more reliable erections. It lasts up to a day and a half, so timing matters less than with Viagra. Human dataPrescription drug
• TAK-653Focus & memory Learning and processing speed. Limited human data
• TB-500Recovery & longevity Pairs with BPC-157 for soft-tissue repair and flexibility. Animal data
• TropisetronFocus & memory My #1 add-on to a stimulant. It "absolutely changed the game for me". Limited human dataPrescription drug